| Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis |
| 論文作者 |
Zheng, JY; Frysz, M; Faber, BG; Lin, HD; Ebsim, R; Ge, JY; Yong, YL; Saunders, FR; Gregory, JS; Aspden, RM; Harvey, NC; Jiang, BH; Cootes, T; Lindner, C; Gao, X; Wang, SJ; Tobias, JH |
| 期刊/會議名稱 |
OSTEOARTHRITIS AND CARTILAGE |
| 論文年度 |
2025 |
| 論文類別 |
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| 摘要 |
Objects: Joint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts. Methods: Left hip iDXA scans were used to quantify rHOA, from a combination of osteophytes (grade >= 1) and joint space narrowing (grade >= 1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle >= 60 degrees) and pincer (lateral centre-edge angle (LCEA) >= 45 degrees) morphology and acetabular dysplasia (LCEA < 25 degrees). Diameter of femoral head (DFH), femoral neck width (FNW), and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height, and weight and stratified by sex. Results: Complete data were available for 5924 SC and 39,020 White UKB participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC. Conclusions: rHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence. (c) 2023 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 卷 |
33 |
| 影響因子 |
9 |
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