| Gemcitabine and cisplatin or oxaliplatin chemotherapy combined with atezolizumab plus bevacizumab for advanced biliary tract cancers: a single-arm trial |
| 論文作者 |
Wang, K; Yu, HM; Xiang, YJ; Cheng, YQ; Ni, QZ; Guo, WX; Shi, J; Feng, S; Zhai, J; Cheng, SQ |
| 期刊/會議名稱 |
FUTURE ONCOLOGY |
| 論文年度 |
2023 |
| 論文類別 |
Article |
| 摘要 |
Advanced biliary tract cancer (BTC) has a poor prognosis, even after combined chemotherapy of gemcitabine and oxaliplatin (GEMOX). To investigate the efficacy and safety of GEMOX chemotherapy combining atezolizumab and bevacizumab in advanced BTC, the authors designed an open-label, single-arm, phase II clinical trial and will enroll patients with stage IV BTC. The participants will receive GEMOX chemotherapy combined with atezolizumab plus bevacizumab. The primary end point is objective response rate; the secondary end points are overall survival, disease control rate, progression-free survival, time to progression, duration of response and safety. The results of this trial are expected to provide novel, safe and effective treatment options for patients with advanced BTC, which could further improve their prognosis. |
| 期 |
15 |
| 卷 |
19 |
| 影響因子 |
3.3 |
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