| Convergent alteration of lung tissue microbiota and tumor cells in lung cancer |
| 論文作者 |
Dong, H; Tan, Q; Xu, YY; Zhu, YQ; Yao, YX; Wang, YZ; Li, C; Li, H; Zhang, GQ; Xiong, Y; Ruan, MH; Zhao, JD; Jin, WR; Lu, LG; Lu, S |
| 期刊/會(huì)議名稱 |
ISCIENCE |
| 論文年度 |
2022 |
| 論文類別 |
Article |
| 摘要 |
Microbiota-host interaction plays an important role in cancer predisposing, initiation, progression, and response to therapy. Here, we explored the composition of lung tissue microbiota in 143 Chinese patients through conducting 16S rRNA gene sequencing, while TP53 mutation in tumor cells was assessed simultaneously. We found PAH-degrading microbes were more abundant in lung tumor microbiota from smokers. Furthermore, TP53 mutation was more prevalent in smokers, and TP53-mutated tumor harbored more Massilia, as well as Acidovorax that was also capable of degrading PAH. Further analysis showed DNA recombination and repair pathway was enriched in microbiota of smokers, which was convergent to the alteration occurred in tumor cells. Meanwhile, the microbiota of TP53-mutated tumor also exhibited dysregulation of p53 signaling pathway. Our results provided insights into the association of lung commensal microbes with tobacco exposure and host gene mutation, suggesting microbiota and tumor cells might undergo convergent alteration and mutually benefit each other. |
| 期 |
1 |
| 卷 |
25 |
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